Viruses are the smallest of all the microbes. They are said to be so small that 500 million rhinoviruses (which cause the common cold) could fit on to the head of a pin. They are unique because they are only alive and able to multiply inside the cells of other living things. The cell they multiply in is called the host cell.
A virus is made up of a core of genetic material, either DNA or RNA, surrounded by a protective coat called a capsid which is made up of protein. Sometimes the capsid is surrounded by an additional spikey coat called the envelope. Viruses are capable of latching onto host cells and getting inside them.
H3N2 influenza virus particles, coloured transmission electron micrograph (TEM). Each virus consists of a nucleocapsid (protein coat) that surrounds a core of RNA (ribonucleic acid) genetic material. Surrounding the nucleocapsid is a lipid envelope that contains the glycoprotein spikes haemagglutinin (H) and neuraminidase (N). These viruses were part of the Hong Kong Flu pandemic of 1968-1969 that killed approximately one million people worldwide. H3N2 viruses are able to infect birds and mammals as well as humans. They often cause more severe infections in the young and elderly than other flu strains and can lead to increases in hospitalisations and deaths.
Viruses only exist to make more viruses. The virus particle attaches to the host cell before penetrating it. The virus then uses the host cell’s machinery to replicate its own genetic material. Once replication has been completed the virus particles leave the host by either budding or bursting out of the cell (lysis).
As the newly formed viral particle pushes against the host cell’s plasma membrane a portion adheres to it. The plasma membrane envelops the virus and becomes the viral envelope. The virus is released from the cell. This process slowly uses up the host’s cell membrane and usually leads to cell death.
The virus particles burst out of the host cell into the extracellular space resulting in the death of the host cell. Once the virus has escaped from the host cell it is ready to enter a new cell and multiply.